発達障害研究所
Institute for Developmental Research
発達障害研究所

 

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神経制御学部 研究業績 (2005~2017)


主な原著論文

2017(H29)

1- Ito H, Morishita R, Nagata K: Autism spectrum disorder-associated genes and the development of dentate granule cells. Med. Mol. Morphol. In press
2- Inoue M, Iwai R, Tabata H, Konno D, Komabayashi-Suzuki M, Watanabe C, Iwanari H, Mochizuki Y, Hamakubo T, Matsuzaki F, Nagata K, Mizutani K: Prdm16 is critical for progression of the multipolar phase during neural differentiation of the developing neocortex. Development. 144: 385-399, 2017.
3- Goto M, Mizuno M, Matsumoto A, Yang Z, Jimbo F.E, Tabata H, Yamagata T, Nagata K: Role of a circadian-relevant gene, NR1D1, in the brain development: possible involvement in the pathophysiology of autism spectrum disorders. Sci. Rep. 7:43945, 2017.
4- Hamada N, Negishi Y, Mizuno M, Miya F, Hattori A, Okamoto N, Kato M, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Tabata H, Saitoh S, Nagata K: Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: Possible involvement in periventricular nodular heterotopia and intellectual disability. J. Neurochem.140: 82-95,2017.

2016(H28)

1- Inaguma Y, Matsumoto A, Noda M, Tabata H, Maeda A, Goto M, Usui D, Jimbo F.E, Kikkawa K, Ohtsuki M, Momoi YM, Osaka H, Yamagata T, Nagata K: Role of Class III phosphoinositide 3-kinase in the brain development: possible involvement in specific learning disorders. J. Neurochem. 139: 245-255,2016.
2- Hamada N, Ito H, Nishijo T, Iwamoto I,  Morishita R, Tabata H, Momiyama T, Nagata K: Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development. Sci. Rep.  6: 30805,2016.
3- Ito H, Morishita R, Nagata K: Schizophrenia susceptibility gene product dysbindin-1 regulates the homeostasis of cyclin D1.
BBA-Molecular Basis of Disease
1862:1383-1391, 2016.
4- Yuan Q, Yang F, Xiao Y, Tan S, Husain N, Ren M, Hu Z, Martinowich K, Ng J S, Kim P J, Han W, Nagata K, Weinberger DR, H. Je S: Regulation of BDNF exocytosis and GABAergic interneuron synapse by the schizophrenia susceptibility gene dysbindin-1. Biol. Psychiatry 80: 312–322, 2016.
5- Tabata H, Nagata K:Decoding the molecular mechanisms of neuronal migration using in utero electroporation. Med. Mol. Morphol. 49.63-75.2016.
6- Ito H, Morishita R, Tabata H, Nagata K: Methods in Cell Biology (Septins) (A. S. Gladfelter Ed.) Visualizing septin and cell dynamics in mammalian brain slices. Elsevier Vol.136 Chapter 17, pp.295-309, 2016.

7- Yang Z, Matsumoto A, Nakayama K, Jimbo F E, Kojima K, Nagata K, Iwamoto S, Yamagata T: Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.
 Brain & Dev. 38: 91-99, 2016
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2015(H27)

1- Hamada N, Ito H, Iwamoto I, Morishita R, Tabata H, Nagata K: Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex. Mol. Autism 6:56, 2015.
2- Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K-I, Ishida M, Tanaka DH, Kawauchi T, Sekine K, Kusuzawa S, Kawasaki T, Hirata T, Tabata H, Uhlén P, Nakajima K : The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain. Proc. Natl. Acad. Sci. USA 112:E4985–94, 2015.
3- Hashimoto H, Yuasa S, Tabata H, Tohyama S, Seki T, Egashira T, Hayashiji N, Hattori F, Kusumoto D, Kunitomi A, Takei M, Kashimura S, Yozu G, Shimojima M, Motoda C, Muraoka N, Nakajima K, Sakaue-Sawano A, Miyawaki A, Fukuda K : Analysis of cardiomyocyte movement in the developing murine heart. Biochem Biophys Res Commun 464:1000–1007, 2015.
4- Inaguma Y, Ito H, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K: Morphological characterization of Class III phosphoinositide 3-kinase during mouse brain development. Med. Mol. Morphol. 49(1).28.33.2016.
5- Lee S-A, Kim S-M, Suh B K, Sun H-Y, Park Y-U, Hong J-H, Park C, Nguyen M D, Nagata K, Yoo J-Y, Park S K: Disrupted-in-schizophrenia 1 (DISC1) regulates dysbindin function by enhancing its stability. J. Biol. Chem. 290: 7087-7096, 2015
6- 浜田奈々子、稲熊 裕、永田浩一: 発達障害の背景としての大脳皮質構築異常(みにれびゅう) 生化学 87, 205-208,
7- Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K: Morphological characterization of mammalian Timeless in the mouse brain development. Neurosci. Res. 92:21-28,2015.
8- Mizuno M, Matsumoto A, Hamada N, Ito H, Miyauchi A, Jimbo F E, Momoi Y M, Tabata H, Yamagata T, Nagata K: Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. J. Neurochem. 132:61-69,2015.

2014(H26)

1- Joliot V, Ait-Mohamed O, Battistl V, Pontis J, Philipot O, Robin P, Ito H, Ait-Si-Ali S: The SWI/SNF subunit/tumor suppressor BAF47/INI1 is essential in cell cycle arrest upon skeletal muscle terminal differentiation. PLOS ONE 9 :e108858, 2014.
 2- Nishimura YV, Shikanai M, Hoshino M, Ohshima T, Nabeshima Y, Mizutani K, Nagata K, Nakajima K, Kawauchi T: Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons. Development 141,3540-3550,2014.
3- Ito H, Morishita R, Iwamoto I, Nagata K: Establishment of an in vivo electroporation method into postnatal newborn neurons in the dentate gyrus. Hippocampus 24:1449-1457,2014.
4- 山形崇倫、松本歩、永田浩一:自閉性障害の多様な遺伝学的病態とシナプス関連病因遺伝子の解析(総説) 脳と発達 46(2) 125-130, 2014.
5- Tanabe K, Yamazaki H, Inaguma Y, Asada A, Kimura T, Takahashi J, Taoka M, Ohshima T, Furuichi T, Isobe T, Nagata K, Shirao T, Hisanaga S: Phosphorylation of Drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. PLOS ONE 9(3): e92291, 2014.
6- Matsumoto A*, Mizuno M*, Hamada N, Nozaki Y, Jimbo E, Momoi M, Nagata K, Yamagata T:LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome. PLOS ONE 9(3): e92695, 2014.
*equal contribution
7- Ito H, Morishita R, Tabata H, Nagata K: Roles of Rho small GTPases in the tangentially migrating neurons. Histol Histopathol. (2014) 29: 871-879
8- Inaguma Y, Hamada N, Tabata H, Iwamoto I, Mizuno M, Nishimura VY, Ito H, Morishita R, Suzuki M, Ohno K, Kumagai T, Nagata K: SIL1, a causative cochaperone gene of Marinesco-Sjögren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex. EMBO Mol. Med. 6: 414–429, 2014
9- Mizutani Y, Iwamoto I, Kanoh H, Seishima M and Nagata K. Expression of Drebrin, an actin binding protein, in basal cell carcinoma, trichoblastoma and trichoepithelioma. Histol Histopathol 29, 757-766, 2014
2013(H25)

1- Mostowy S, Bi E, Fuchtbauer EM, Goryachev AG, Montagna C, Nagata K, Trimble WS, Werner HB, Yao X, Zieger B and Spiliotis ET. Septin assembly in China: Meeting report of the 2013 International Conference on Septin Biology. Biol. Chem. 395, 119–121, 2013
2- Xie M, Yagi H, Kuroda K, Wang C.C, Munekazu K, Zhao H, Sakakibara A, Miyata T, Nagata K, Iguchi T, Sato M: WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. Cerebral Cortex 23: 1410-23, 2013.
3- Tabata H, Hachiya T, Nagata K, Sakakibara Y, Nakajima K:
Screening For Candidate Genes Involved In The Production Of Mouse Subventricular Zone Proliferative Cells And An Estimation Of Their Changes In Evolutionary Pressure During Primate Evolution.
Frontiers in Neuroanatomy 7:24, 2013.
4- Ito H, Morishita R, Iwamoto I, Mizuno M, Nagata K: MAGI-1 acts as a scaffolding molecule for NGF receptor-mediated signaling pathway. Biochim. Biophys. Acta – Mol. Cell Res.1833:2302-2310, 2013.
5- Hamada N, Ito H, Iwamoto I, Mizuno M, Morishita R, Inaguma Y, Kawamoto S, Tabata H, Nagata K: Biochemical and morphological characterization of A2BP1 in the neuronal tissue. J. Neurosci. Res.91:1303-1311, 2013.
6- Mizutani Y, Ito H, Iwamoto I, Morishita R, Kanoh H, Seishima M, Nagata K. Possible role of a septin, SEPT1, in spreading in squamous cell carcinoma DJM-1 cells. Biol. Chem. 394: 281-290, 2013.
7- Mizuno M, Sotoyama H, Namba H, Shibuya M, Eda T, Wang R, Okubo T, Nagata K, Iwakura Y, Nawa H ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia; Implication of their dopamine-modulatory actions. Translational Psychiatry 3:e252, 2013
2012(H24)

1- Yamauchi M, Sudo K, Ito H, Iwamoto I, Morishita R, Murai T, Kajita K, Ishizuka T and Nagata K: Localization of a multi-domain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka-Long-Evans-Tokushima Fatty rats.   Med. Mol. Morphol. 46:41-48,2013
2- Ito H, Morishita R, Sudo K, Nishimura VY, Inaguma Y, Iwamoto I, Nagata K: Biochemical and morphological characterization of MAGI-1 in the neuronal tissue. J. Neurosci. Res. 90:1776-1781,2012
3- Murase K, Ito H, Kanoh H, Sudo K, Iwamoto I, Morishita R, Soubeyran P, Seishima M, Nagata K: Cell biological characterization of a multi-domain adaptor protein, ArgBP2, in  epithelial NMuMG cells, and identification of a novel short isoform. Med. Mol. Morphol. 15:22-28,2012 
4- Nishimura VY, Shinoda T, Ito H, Nagata K: Application of in utero electroporation and live imaging in the analyses of neuronal migration during mouse brain development. Med. Mol. Morphol. (Review)  45:1-6,2012
 
2011(H23)

1- Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y : UV-sensitive photoreceptor protein OPN5 in humans and mice. PLos ONE 6 : e26388, 2011
2- Hamatake M, Miyazaki N, Sudo K, Matsuda M, Sadakata T, Furuya A, Ichisaka S, Hata Y, Nakagawa C, Nagata K, Furuichi T, Katoh-Semba R: Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats
J. Biol. Chem. 286: 21478–21487, 2011
 
2010(H22)

1- Ito H, Morishita R, Shinoda T, Iwamoto I, Sudo K, Okamoto K, Nagata K: Dysbindin-1, a schizophrenia-related molecule, is involved in the regulation of neuronal dendritic development.  Mol Psychiatry 15: 969, 2010 (IMAGE)
2- Ito H, Morishita R, Shinoda T, Iwamoto I, Sudo K, Okamoto K, Nagata K: Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Mol. Psychiatry  15:976-986,2010  
3- Shinoda T, Ito H, Sudo K, Iwamoto I, Morishita R and Nagata K: Septin 14 is involved in cortical neuronal migration via interaction with Septin 4.  Mol. Biol. Cell 21, 1324-1334, 2010
 
2009(H21)

1- Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K: Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein. J Neurochem 110:1567-1574, 2009
2- Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G: TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.  J Biol. Chem. 284, 22059-22066, 2009
3- Li X, Serwanski DR, Miralles CP, Nagata K, De Blas AL: Septin 11 is present in gabaergic synapses and plays a functional role in the cytoarchitecture of neurons and gabaergic synaptic connectivity.J Biol Chem, 284, 17253-17265, 2009
4- Nagata K, Ito H, Iwamoto I, Morishita R, Asano T: Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. Med Mol Morphol 42: 9-15, 2009. 
 
2008(H20)

1- Caron D, Winstall E, Inaguma Y, Michaud S, Lettre F, Bourassa S, Kelly I, Poirier GG, Faure RL, Tanguay RM: Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated. J Proteome Res 7: 4492-4499, 2008. 
2- Ito H, Atsuzawa K, Morishita R, Usuda N, Sudo K, Iwamoto I, MizutaniK, Katoh-Semba R, Nozawa Y, Asano T, Nagata K:Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. J Neurochem 108: 867-880, 2008.
3- ItoH, Atsuzawa K, Sudo K, Di Stefano P, Iwamoto I, Morishita R, Takei S, Semba R, Defilippi P, Asano T, Usuda N, Nagata K: Characterization of a multi-domain adaptor protein, p140Cap, as part of a presynaptic complex. J Neurochem 107:61-72, 2008.
4- Katoh-Semba R, Tsuzuki M, Miyazaki N, Matsuda M, Nakagawa C, Ichisaka S, Sudo K, Kitajima S, Hamatake M, Hata Y, Nagata K: A phase advance of the light-dark cycle stimulates production of BDNF, but not of other neurotrophins, in the adult rat cerebral cortex: association with the activation of CREB. J Neurochem 106: 2131-2142, 2008.
5- Maimaitiyiming M, Kumanogoh H, Nakamura S, Nagata K, Suzaki T, Maekawa S:Biochemical characterization of membrane-associated septin from rat brain. J Neurochem 106: 1175-1183, 2008.
 
2007(H19)

1- Ueda H, Nagae R, Kozawa M, Morishita R, Kimura S, Nagase T, Ohara O, Yoshida S, Asano T: Heterotrimeric G protein bg subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. J Biol Chem 283: 1946-1953, 2008.
2- Mizutani K, Nagata K, Ito H, Ehara H, Nozawa Y, Deguchi T: Possible roles of vinexinb in growth and paclitaxel sensitivity in human prostate cancer PC-3 cells. Cancer Biol Ther 6: 1800-1804, 2007.
3- Banu S, Ichihara S, Huang F, Ito H, Inaguma Y, Furuhashi K, Fukunaga Y, Wang Q, Kitoh J, Ando H, Kikkawa F, Ichihara G: Reversibility of the adverse effects of 1-bromopropane exposure in rats. Toxicol Sci 100: 504-512, 2007.
4- Hara A, Taguchi A, Niwa M, Aoki H, Yamada Y, Ito H, Nagata K, Kunisada K, Mori H: Localization of septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of photoreceptor cell degeneration. Neurosci Lett 423: 205-210, 2007.
5- Morishita R, Ueda H, Ito H, Takasaki J, Nagata K, Asano T: Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation. Neurosci Res 59: 205-214, 2007.
6- Mizutani K, Ito H, Iwamoto I, Morishita R, Deguchi T, Nozawa Y, Asano T, Nagata K: Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth. Oncogene 26: 7122-7131, 2007.
7- Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K: SEPT9 sequence alterations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling. Hum Mut 28: 1005-1013, 2007.
8- Morishita R, Nagata K, Ito H, Ueda H, Asano M, Shinohara H, Kato K, Asano T: Expression of smooth muscle cell-specific proteins in neural progenitor cells Induced by agonists of G protein-coupled receptors and transforming growth factor-β. J Neurochem 101: 1031-1040, 2007.
9- Ito H, Usuda N, Atsuzawa K, Iwamoto I, Sudo K, Katoh-Semba R, Mizutani K, Morishita R, Deguchi T, Nozawa Y, Asano T, Nagata K: Phosphorylation by extracellular signal-regulated kinase of a multi-domain adaptor protein, vinexin, at synapses. J Neurochem 100: 545-554, 2007.  
 
2006(H18)

1- Sudo K, Ito H, Iwamoto I,Morishita R, Asano T, Nagata K:Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. Neurosci Res 56: 347-355, 2006.
2- Ito H, Iwamoto I, Mizutani K, Morishita R, Deguchi T, Nozawa Y, Asano T, Nagata K: Possible interaction of a Rho effector, Rhotekin, with a PDZ-protein, PIST, at synapses of hippocampal neurons. Neurosci Res 56: 165-171,2006.
3- Ito H, Iwamoto I, Morishita R, Nozawa Y, Asano T, Nagata K: Identification of a PDZ-protein, PIST, as a binding partner for Rho-effector Rhotekin: Biochemical and cell biological characterization of Rhotekin-PIST interaction. Biochem J 397: 389-398, 2006.
 
2005(H17)

1- Ito H, Ueda H, Iwamoto I, Inaguma Y, Takizawa T, Asano T, Kato K: Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells. J Cell Physiol 202 : 874-879, 2005.
2- Nagata K, Inagaki M: Cytoskeletal Modification of a Rho Guanine Nucleotide Exchange Factor Activity: Identification of a novel Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin. Oncogene 24: 65-76, 2005.
3- Nishizawa M, Izawa I, Inoko A, Hayashi Y, Nagata K, Yokoyama T, Usukura J, Inagaki M: Identification of trichoplein, a novel keratin filament-binding protein. J Cell Sci 118: 1081-1090, 2005.
4- den Engelsman J, Gerrits D, de Jong WW, Robbins J, Kato K, Boelens WC: Nuclear import of αB-crystallin is phosphorylation-dependent and hampered by hyperphosphorylation of the myopathy-related mutant R120G. J Biol Chem 280: 37139-37148, 2005.
5- Yasuda E, Kumada T, Takai S, Ishisaki A, Noda T, Matsushima-Nishiwaki R, Yoshimi N, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kozawa O: Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma. Biochem Biophys Res Commun 337: 337-342, 2005.
6- Ito H, Iwamoto I, Inaguma Y, Takizawa T, Nagata K, Asano T, Kato K: Endoplasmic reticulum stress induces the phosphorylation of small heat shock protein, Hsp27. J Cell Biochem 95: 932-941, 2005.
7- Stefanovic S, Windsor M, Nagata K, Inagaki M, Wileman T: Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II. J Virol 79: 11766-11775, 2005.
8- Ito H, Iwamoto I, Morishita R, Nozawa Y, Narumiya S, Asano T, Nagata K: Possible role of Rho/Rhotekin signaling in mammalian septin organization. Oncogene 24: 65-76, 2005.
9- Ono R, Ihara M, Nakajima H, Ozaki K, Kataoka-Fujiwara Y, Taki T, Nagata K, Inagaki M, Yoshida M, Kitamura T, Hayashi Y, Kinoshita M, Nosaka T: Disruption of Sept6, a fusion partner gene of mixed lineage leukemia (MLL), does not affect the ontogeny, leukemogenesis induced by MLL-SEPT6, or the phenotype induced by the loss of Sept4. Mol Cell Biol 25: 10965-10978, 2005.
 
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