病理学部　研究業績

Hasegawa-Ishii S, Inaba M, Umegaki H, Unno K, Wakabayashi K and *Shimada A : Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain–immune interface. Scientific Reports (in press, 2016)

Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y, Takei S, Maruyama K, Shimizu T, Shimada A: Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. Prostaglandins Leukot. Essent. Fatty Acids 88:373–381, 2013.

Hasegawa-Ishii S, Shimada A, Inaba M, Li M, Shi M, Kawamura N, Takei S, Chiba Y, Hosokawa M, Ikehara S: Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus. Brain Behav. Immun. 29:82-97, 2013.

Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M and *Tanaka M : Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics 14: 248, 2013

Takei, S, Hasegawa-Ishii, S, Uekawa, A, Chiba, Y, Umegaki, H, Hosokawa, M, Woodward, DF, Watanabe, K, Shimada, A: Immunohistochemical demonstration of increased prostaglandin F_2α levels in the rat hippocampus following kainic acid-induced seizures. Neuroscience 218: 295-304, 2012.

Ohgami N, Ida-Eto M, Sakashita N, Sone M, Nakashima T, Tabuchi K., Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G. Jijiwa M, Asai N, Hara A, Takahashi M, Kato M. Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiol. Agng 33: 626. e25-34, 2012.

Chiba Y, Takei S, Kawamura N, Kawaguchi Y, Sasaki K, Hasegawa-Ishii S, Furukawa A, Hosokawa M, Shimada A. Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy. Neuropathol. Appl. Neurobiol. 38: 559-71, 2012.

Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A: Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Brain Res. 1367: 22-32, 2011.

Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Shimada A: Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain Behav. Immun. 25: 83-100, 2011.

Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M, Shimada A: Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice. Neuropathology 31: 20-28, 2011.

Kouchi Z, Igarashi T, Shibayama N, Inanobe S, Sakurai K., Yamaguchi H, Fukuda T, Yanagi S, Nakamura Y, Fukami K: Phospholipase Cd3 regulates RhoA/Rho kinase signaling and neurite outgrowth. J. Biol. Chem. 286: 8459-8471, 2011.

Kouchi Z, Fujiwara Y, Yamaguchi H, Nakamura Y,Fukami K: Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem. Biophys. Res. Commun. 408: 523-529, 2011.

Furukawa A, Kawamoto, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A: Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury. Neurobiol. Dis. 43:706-714, 2011.

Hoshino S, Kurishima A, Inaba M, Ando Y, Fukui T, Uchida K, Nishio A, Iwai H, Yokoi T， Ito T, Hasegawa-Ishii S, Shimada A, Li M, Okazaki K, Ikehara S: Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells. J. Gastroenterol. 46: 1368-1381, 2011.

Takei S, Tokuhira Y, Shimada A, Hosokawa M, Fukuoka S: The eosin-shadow method: A selective enhancement of light microscopic visualization of pancreatic zymogen granules on hematoxylin-eosin sections. Anat. Sci. Int. 85: 245-250, 2010.

Furukawa A, Oikawa S, Hasegawa-Ishii S, Chiba Y, Kawamura N, Takei S, Yoshikawa K, Hosokawa M, Kawanishi S, Shimada A: Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration. Mech. Ageing Dev. 131: 379-388, 2010.

Furukawa A, Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S: Oxidatively generated DNA damage induced by 3-amino-5-mercapto- 1,2,4-triazole, a metabolite of carcinogenic amitrole. Mutat. Res. 694: 7-12, 2010.

Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, Fukami K: Phospholipase C-eta2 is highly expressed in the habenula and retina. Gene Expr. Patterns 10: 119-126, 2010.

Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M: c-Ret-mediated hearing loss in mice with Hirschsprung disease. Proc. Natl. Acad. Sci. USA 107: 13051-13056, 2010.

Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H: Mutant Huntingtin impairs Ku70-mediated DNA repair. J. Cell Biol. 189: 425-443, 2010.

Chiba Y, Shimada A, Yoshida F, Keino H, Hasegawa M, Miyake S, Ikari H, Hosokawa M: Falls in adults with intellectual disability: risk factors and risk assessment. Am. J. Intellect. Dev. Disabil. 114: 225-236, 2009.

Oikawa S, Yamada T, Minohata T, Kobayashi H, Furukawa A, Tada-Oikawa S, Hiraku Y, Murata M, Kikuchi M, Yamashima T: Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion.  Free Radic. Biol. Med. 46: 1472-1477, 2009.

Shimada A, Keino N, Kawamura N, Chiba Y, Hosokawa M; Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: a model of cerebral degeneration. Neuropathol. Appl. Neurobiol. 34: 33-51, 2008.

Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Otani H, Higami Y, Ingram DK, Shimokawa I: Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence- accelerated mouse strain P8. Exp. Gerontol. 43: 339-346, 2008.

Saitoh Y, Matsui F, Chiba Y, Kawamura N, Keino H, Satoh M, Kumagai N, Ishii, S, Yoshikawa K, Shimada A, Maeda N, Oohira A, Hosokawa M: Reduced Expression of MAb6B4-Epitopes on Chondroitin Sulfate Proteoglycan Aggrecan in Perineuronal Nets from the Cerebral Cortices of SAMP10 Mice, a Model for Age-Dependent Neurodegeneration. J. Neurosci. Res. 86: 1316-1323, 2008.

Satoh M, Shimada A, Kawamura N, Chiba Y, Yoshikawa K, Ishii S, Furukawa A, Kumagai N, Hosokawa M: Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level. Neuropathology 28: 485-496, 2008.

Sasaki T, Unno K, Tahara S, Shimada A, Chiba Y, Hoshino M, Kaneko T: Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell 7: 459-469, 2008.

石井さなえ，千葉陽一，梅垣宏行，井口昭久，河村則子，吉川圭介，古川絢子，武井史郎，細川昌則，島田厚良: 加齢性神経変性に対するミクログリアの機能解明にむけて．基礎老化研究 32: 21-24, 2008.

Ohtsuki B, Matsumura T, Shimizu M, Mori M, Okudaira S, Nakanishi R, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T: Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice. J. Bone Mineral Res. 22: 675-685, 2007.

Chiba T, Yao J, Higami Y, Shimokawa I, Hosokawa M, Higuchi K: Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtraction hybridization analysis. Mamm. Genome 18: 105-112, 2007.

Hasegawa (Ishii) S, Yamaguchi M, Nagao H, Mishina M, Mori K: Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. J. Neuroimmunology 186: 75-85, 2007.

Kumagai N, Chiba Y, Hosono M, Fujii M, Kawamura N, Keino H, Yoshikawa K, Ishii S, Saitoh Y, Satoh M, Shimada A, Hosokawa M: Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse. Brain Res. 1185: 75-85, 2007.

Furukawa A, Tada-Oikawa S, Kawanishi S, Oikawa S: H²O² accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD₊ depletion. Cell Physiol. Biochem. 20: 45-54, 2007.

Shimada A, Tsuzuki M, Keino H, Satoh M, Chiba Y, Saitoh Y, Hosokawa M: Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration. Neuropathol. Appl. Neurobiol. 32: 1-14, 2006.

Chiba Y, Shimada A, Satoh M, Saitoh Y, Kawamura N, Hanai A, Keino H, Ide Y, Shimizu T, Hosokawa M: Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system. Neuroscience 141: 917-927, 2006.

Yoshikawa K, Kita Y, Kishimoto K, Shimizu T: Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure. J. Biol. Chem. 281: 14663-14669, 2006.

Shimizu K, Fukunaga S, Yoshikawa K, Kondo R: Screening of extracts of Japanese woods for melanin biosynthesis inhibition. J. Wood Sci. 53: 153-160, 2006.

Nakanishi R, Shimizu M, Mori M, Akiyama H, Okudaira S, Otsuki B, Hashimoto M, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T: Secreted Frizzled-Related Protein 4 is a Negative Regulator of Peak BMD in SAMP6 Mice. J. Bone Mineral Res. 21: 1713-1721, 2006.

Aono S, Tokita Y, Yasuda Y, Hirano K, Yamauchi S, Shuo T, Matsui F, Keino H, Kashiwai A, Kawamura N, Shimada A, Kishikawa M, Asai M, Oohira A: Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain. J. Neurosci. Res. 83: 110-118, 2006.

Ueno M, Tomita S, Nakagawa T, Ueki M, Iwanaga Y, Ono J, Onodera M, Huang CL, Kanenishi K, Shimada A, Maekawa N, Sakamoto H: Effects of aging and HIF-1a deficiency on permeability of hippocampal vessels. Microsc. Res. Tech. 69: 29-35, 2006.

Hosokawa M, Ashida Y, Saitoh Y, Shoji M: Aging of eyes and ears in SAM mice. In: Takeda T et al. (eds.) The senescence-accelerated mouse (SAM): Achievements and Future Directions. Amsterdam, Elsevier, (in press)

Hosokawa M, Fujisawa-Tsukaguchi H, Chiba Y: Accelerated age- associated genetic damage in SAMP mice. In: Takeda T et al. (eds.) The senescence-accelerated mouse (SAM): Achievements and Future Directions. Amsterdam, Elsevier, (in press)

Hosokawa M, Sakura M, Chiba Y, Appendix II. The Grading Score System: A method for evaluating the degree of senescence in SAM strains of mice. In: Takeda T et al. (eds.) The senescence-accelerated mouse (SAM): Achievements and Future Directions. Amsterdam, Elsevier, (in press)

Shimada A, Hasegawa-Ishii S, Furukawa A : SAMP10 strain as a model for the study of brain aging, In “The senescence-accelerated mouse (SAM): Achievements and Future Directions” (Ed.) Takeda T, Akiguchi I, Higuchi K, Hosokawa M, Hosokawa T and Nomura Y, pp 157-174, Elsevier, Amsterdam, 2013.

Chiba Y, Fujisawa-Tsukaguchi H, Nishikawa T, Hosokawa M: Higher oxidative stress status and mitochondrial alterations as a possible mechanism for senescence acceleration. In: Takeda T et al. (eds.) The senescence-accelerated mouse (SAM): Achievements and Future Directions. Amsterdam, Elsevier, (in press)

Enokido Y，Okazawa H： DNA repair in the nervous system: a new research for neurological disorders.  In: DNA Research, Genetics and Cell Biology 3, Nova Science Publishers, New York, pp79-105, 2012.

島田厚良，石井さなえ：「脳と免疫系の相互作用という観点から老化促進モデルマウスをとらえる」　基礎老化研究 36(1):13-20,2012.

榎戸 靖：「発達障害と神経変性に関わる新たな神経細胞死メカニズム」　日本神経精神薬理学会雑誌，32:31-35，2012.

榎戸　靖，岡澤　均：「ポリグルタミン病におけるDNA修復異常」メディカル・サイエンス・ダイジェスト　38(1):21-24, 2012.

Shimada  A，Hasegawa-Ishii S： Senescence-accelerated mice (SAMs) as a model for brain aging and immunosenescence. Aging Dis. 2:414-436, 2011

島田厚良，石井さなえ：「免疫系と神経系の接点から老化促進モデルマウスをとらえる」，日本老年医学会雑誌　48: 439-446，2011.

林　雅晴，小森　拓，島田厚良：Clinical Pathological Conference (C.P.C.) 学業の遅れと歩行の異常で発症し、多彩な神経症状が進行した男子症例．「小児神経学の進歩-第39集」（日本小児神経学会教育委員会編）診断と治療社　pp129-144, 2010.

古川絢子，及川伸二：「酸化ストレスに着目したプロテオミクス解析—モデル動物を用いた酸化損傷蛋白質の網羅的解析—」内分泌・糖尿病・代謝内科　30(4); pp319-326, 2010.

細川昌則，千葉陽一，塚口（藤澤）裕美：老化モデル：マウス．In:新老年学　第３版　大内尉義，秋山弘子編（東京大学出版会）pp237-240, 2010.

Chiba Y, Shimada A, Kumagai N, Yoshikawa K, Ishii S, Furukawa A, Takei S, Sakura M, Kawamura N, Hosokawa M: The Senescence-accelerated Mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model. Neurochem.Res 34: 679-87, 2009.

及川伸二，古川絢子，村田真理子；川西正祐: 酸化ストレスによるDNAやタンパク質の損傷を介した老化促進機構．基礎老化研究 33(1): 9-16, 2009.

島田厚良: 脳老化病態モデル動物を用いた脳の形態学的解析．（日本基礎老化学会編）「老化・老年病研究のための動物実験ガイドブック」アドスリー pp45-51, 2008.

細川昌則、千葉陽一: SAM マウス．（日本基礎老化学会編）「老化・老年病研究のための動物実験ガイドブック」アドスリー pp90-100, 2008.

Saitoh Y, Chiba Y, Shimada A: Aging and proteoglycans. Neural Proteoglycans (Maeda N, ed), Research Signpost, Kerala, pp183-199, 2007.