| 原著論文 |
| 2017年 |
| 1 |
Teraishi M, Takaishi M, Nakajima K, Ikeda M, Higashi Y, Shimoda S, Asada
Y, Hijikata A, Ohara O, Hiraki Y, Mizuno S, Fukada T, Furukawa T, Wakamatsu
N, Sano S. Critical involvement of ZEB2 in collagen fibrillogenesis: the
molecular similarity between Mowat-Wilson syndrome and Ehlers-Danlos syndrome.
Scientific Reports 2017 (in press) |
| 2 |
Goto H, Machida J, Shibata A, Tatematsu T, Osumi E, Miyachi H, Takahashi
K, Nakayama A, Higashi Y, Nagao T, Shimozato K, Tokita Y. Novel RUNX2/CBFA1
mutation in the runt domain in a Japanese patient with cleidocranial dysplasia. J Oral and Maxillofac Surg, Med and Pathol. 2017 (in press) |
| 3 |
Nakanishi K, Sato Y, Mizutani Y, Ito M, Hirakawa A, Higashi Y. Rat umbilical
cord blood cells attenuate hypoxic–ischemic brain injury in neonatal rats. Scientific Reports 7, Article number: 44111. 2017
|
| 4 |
Muramatsu Y, Tokita Y, Mizuno S, Nakamura M. Disparities in visuo-spatial
constructive abilities in Williams syndrome patients with typical deletion
on chromosome 7q11.23. Brain Dev. 39:145-153. 2017
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| 2016年 |
| 1 |
Wu, X., Briseño, C. G., Grajales-Reyes, G. E., Haldar, M., Iwata, A., Kretzer,
N. M., Wumesh, KC., Tussiwand, R., Higashi, Y., Murphy, T. L., and Murphy,
K. M. Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic
cell and monocyte fate. Proc Natl Acad Sci U S A. 113:14775-14780. 2016 |
| 2 |
Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki
Y, Higashi Y, Salant DJ, Maas RL, Lu W. Loss of Zeb2 in mesenchyme-derived
nephrons causes primary glomerulocystic disease. Kidney Int. 90:1262-1273. 2016
|
| 3 |
Ohayon
D, Garcès A, Joly W, Soukkarieh C, Takagi T, Sabourin JC, Agius E, Darling DS,
De Santa Barbara P, Higashi Y, Stolt CC, Hugnot JP, Richardson WD, Carroll P,
Pattyn A. Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular
Zone Involves the Zeb1 Transcription Factor. Cell Rep. 17:1473-1481. 2016
|
| 4 |
Menuchin-Lasowski Y, Oren-Giladi P, Xie Q, Ezra-Elia R, Ofri R, Peled-Hajaj
S, Farhy C, Higashi Y, Van de Putte T, Kondoh H, Huylebroeck D, Cvekl A,
Ashery-Padan R. Sip1 regulates the generation of the inner nuclear layer
retinal cell lineages in mammals. Development. 143:2829-2841. 2016
|
| 5 |
Johmura Y, Yamashita E, Shimada M, Nakanishi K, Nakanishi M.
Defective DNA repair increases susceptibility to senescence through
extension of Chk1-mediated G2 checkpoint activation. Sci Rep. 6:31194. 2016 |
| 6 |
Shimada M, Goshima T, Matsuo H, Johmura Y,
Haruta M, Murata K, Tanaka H, Ikawa M, Nakanishi K, Nakanishi M. Essential role of autoactivation circuitry on
Aurora B-mediated H2AX-pS121 in mitosis.
Nat Commun. 7:12059. 2016
|
| 7 |
Johmura
Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto T,
Okabe A, Aburatani H, Li S, Miyoshi I, Takahashi S, Kitagawa M, Nakanishi
M. SCF(Fbxo22)-KDM4A targets methylated
p53 for degradation and regulates senescence.
Nat Commun. 7:10574. 2016
|
| 8 |
Yasumi
T, Inoue M, Maruhashi M, Kamachi Y, Higashi Y, Kondoh H, Uchikawa M. Regulation of trunk neural crest delamination
by δEF1 and Sip1 in the chicken embryo. Dev Growth Differ. 58:205-14. 2016
|
| 9 |
Shibata
A, Machida J, Yamaguchi S, Kimura M, Tatematsu T, Miyachi H, Matsushita M,
Kitoh H, Ishiguro N, Nakayama A, Higashi Y, Shimozato K, Tokita Y. Characterisation of novel RUNX2 mutation with
alanine tract expansion from Japanese cleidocranial dysplasia patient.
Mutagenesis. 31:61-67. 2016
|
| 2015年 |
|
|
| 1. |
Choi JK,
Zhu A, Jenkins BG, Hattori S, Kil KE, Takagi T, Ishii S, Miyakawa T, Brownell
AL. Combined behavioral studies and in vivo imaging of inflammatory response
and expression of mGlu5 receptors in schnurri-2 knockout mice. Neurosci Lett. 609:159-164. 2015
|
| 2. |
Omilusik
KD, Best JA, Yu B, Goossens S, Weidemann A, Nguyen JV, Seuntjens E, Stryjewska
A, Zweier C, Roychoudhuri R, Gattinoni L, Bird LM, Higashi Y, Kondoh H,
Huylebroeck D, Haigh J, Goldrath AW. Transcriptional repressor ZEB2 promotes
terminal differentiation of CD8+ effector and memory T cell populations during
infection. J Exp Med. 212:2027-2039. 2015
|
| 3. |
Takagi
T, Nishizaki Y, Matsui F, Wakamatsu N, Higashi Y. De novo inbred heterozygous Zeb2/Sip1 mutant
mice uniquely generated by germ-line conditional knockout exhibit craniofacial,
callosal and behavioral defects associated with Mowat-Wilson syndrome. Hum Mol Genet. 24:6390-402. 2015
|
| 4. |
Tatematsu
T, Kimura M, Nakashima M, Machida J, Yamaguchi S, Shibata A, Goto H, Nakayama
A, Higashi Y, Miyachi H, Shimozato K, Matsumoto N, Tokita Y. An aberrant splice acceptor site due to a
novel intronic nucleotide substitution in MSX1 gene is the cause of congenital
tooth agenesis in a Japanese family. PLoS One. 10:e0128227. 2015
|
| 5. |
Hattori
T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, Kotani T, Hirata H,
Hirakawa A, Suzuki S, Tsuji M, Ikeda T, Nakanishi K, Kojima S, Blomgren K,
Hayakawa M. Administration of umbilical
cord blood cells transiently decreased hypoxic-ischemic brain injury in
neonatal rats. Dev Neurosci. 37:95-104. 2015
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| 2014年 |
| 1. |
Yamaguchi S, Machida J, Kamamoto M, Kimura M, Shibata A, Tatematsu T, Miyachi H, Higashi Y, Jezewski P, Nakayama A, Shimozato K, Tokita Y. Characterization of novel MSX1 mutations identified in Japanese patients with nonsyndromic tooth agenesis.
PLoS One. 9:e102944. 2014 |
| 2. |
Sagawa H, Terasaki H, Nakanishi K, Tokita Y, Watanabe M.
Regeneration of optic nerve fibers with unoprostone, a prostaglandin-related antiglaucoma drug, in adult cats.
Jpn J Ophthalmol. 58:100-109. 2014 |
| 3. |
Nishizaki Y, Takagi T, Matsui F, Higashi Y.
SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse.
Genesis. 52:56-67. 2014 |
| 4. |
Kimura M, Machida J, Yamaguchi S, Shibata A, Tatematsu T, Miyachi H, Jezewski PA, Nakayama A, Higashi Y, Shimozato K, Tokita Y.
Novel nonsense mutation in MSX1 in familial nonsyndromic oligodontia: subcellular localization and role of homeodomain/MH4.
Eur J Oral Sci. 122:15-20. 2014 |
| 2013年 |
| 1 |
Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H, Nakanishi M.
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
Nature. 502:249-253. 2013 |
| 2 |
McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck
D, Higashi Y, Rubenstein JL. Dlx1&2-dependent expression of Zfhx1b
(Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
Neuron. 77: 83-98, 2013 |
| 3 |
Mastushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Tokita Y, Ishiguro N.A novel in-frame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia. J Bone Miner Metab. 32:96–99 2013
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| 2012年 |
| 1. |
Weng, Q., Chen, Y., Wang, H., Xu, X., Yang, B., He, Q., Shou, W., Chen, Y., Higashi, Y., van den Berghe, V., Seuntjens, E., Kernie, S.G., Bukshpun, P., Sherr, E.H., Huylebroeck, D. and Lu, Q.L. Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System. Neuron. 73: 713-728, 2012 |
| 2. |
Suzuki K, Yokoyama C, Higashi Y, Daikoku T, Mizoguchi S, Saika S, Yamada G.
Wakayama symposium: epithelial-mesenchymal interaction regulates tissue formation and characteristics: insights for corneal development. Ocul Surf.10: 217-220, 2012 |
| 3. |
Nakanishi K, Ito M, Sato Y, and Oohira A. A highly-sulfated chondroitin sulfate, CS-E, adsorbs specifically to neurons with nuclear condensation. Neurosci. Res. 74: 223-229, doi: 10.1016/j.neures.2012.08.009., 2012 |
| 4. |
Ichinohashi Y, Sato Y, Saito A, Ito M, Watanabe K, Hayakawa M, Nakanishi K, Wakatsuki A, Oohira A. Dexamethasone administration to the neonatal rat results in neurological dysfunction at the juvenile stage even at low doses. Early Hum Dev. doi:pii: S0378-3782(12)00250-2. 10.1016/j.earlhumdev.2012.10.007. [Epub ahead of print], 2012 |
| 2011年 |
| 1. |
Kurima, K., Hertzano, R., Gavrilova, O., Monahan, K., Shpargel, K. B.,
Nadaraja, G., Kawashima, Y., Lee, K. Y., Ito, T., Higashi, Y., Eisenman,
D. J., Strome, S. E. and Griffith, A. J. A noncoding point mutation of
zeb1 causes multiple developmental malformations and obesity in twirler
mice. PLoS Genet. 7: e1002307. (2011) |
| 2. |
Yamada Y, Yoshida F, Hemmi H, Ito M, Kakita H, Yoshikawa T, Hishida M,
Iguchi T, Seo T, Nakanishi K. Atypical social development in neonatal
intensive care unit survivors at 12 months. Pediatr Int. 53:858-66, 2011 |
| 3. |
Kamamoto M, Machida J, Yamaguchi S, Kimura M, Ono T, Jezewski PA, Higashi
Y, Nakayama A, Shimozato K, Tokita Y. Clinical and functional data
implicate the Arg(151)Ser variant of MSX1 in familial hypodontia. Eur J Hum Genet. 19:844-850, 2011 |
| 4. |
Kamamoto M１, Machida J１, Miyachi H１, Ono T２, Nakayama A, Shimozato K１, Tokita Y (１Aichi Gakuin Univ, ２Riken) : A novel mutation in the C-terminal region of RUNX2/CBFA1 distal to the DNA-binding runt domain in a Japanese patient with cleidocranial dysplasia. Int J Oral Maxillofac Surg 40: 434-437, 2011. |
| 2010年 |
| 1. |
Jin JZ１, Tan M１, Warner DR１, Darling DS１, Higashi Y, Gridley T２, Ding J１ (１Univ Louisville, ２Jackson Lab): Mesenchymal cell remodeling during mouse secondary palate
reorientation. Dev Dyn 239: 2110-2117, 2010. |
| 2. |
Nakanishi K, Tokita Y, Aono S, Ida M１, Matsui F, Higashi Y, Oohira A２ (１Mie Univ, ２Aichi Med Univ) : Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan,
interacts with pleiotrophin, a heparin-binding growth factor. Neurochem Res 35: 1131-1137, 2010. |
| 3. |
Yamada K, Miura K１, Hara K２, Suzuki M１, Nakanishi K, Kumagai T１, Ishihara N, Yamada, Kuwano R２, Tsuji S３, Wakamatsu N (１Ctrl Hosp, ２Niigata Univ, ３Tokyo Univ): A wide spectrum of clinical and brain MRI findings in patients
with SLC19A3 mutations. BMC Med Genet 11: 171, 2010. |
| 2009年 |
| 1. |
Ito H, Atsuzawa K1, Morishita R, Usuda N1, Sudo K, Iwamoto I, Mizutani K2, Katoh-Semba R, Nozawa Y2, Asano T, Nagata K (1Fujita Health Univ; 2Gifu International Inst) : Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. J Neurochem 108: 867–880, 2009. |
| 2. |
Inuzuka T1, Tsuda M1, Tanaka S1, Kawaguchi H1, Higashi Y, Ohba Y1 (1Hokkaido Univ): Integral role of transcription factor 8 in the negative
regulation of tumor angiogenesis. Cancer Res 69: 1678-1684, 2009. |
| 3. |
Bui T1, Sequeira J1, Wen T-C1, Sola A2, Higashi Y, Kondoh H3, Genetta, T1 (1Emory Univ, 2Mid Atlantic Neonatol Assoc, 3Osaka Univ): ZEB1 Links p63 and p73 in a novel neuronal survival pathway
rapidly induced in response to cortical ischemia. PLoS ONE 4: e4373, 2009. |
| 4. |
Saito A1, 2, Matsui F, Hayashi K2, Watanabe K2, Ichinohashi Y2, Sato Y1, Hayakawa M1, Kojima S1, Oohira A2 (1Nagoya Univ, 2 Aichi Med Univ): Behavioral abnormalities of fetal growth retardation model rats with reduced amounts of brain proteoglycans. Exp Neurol 219: 81-92, 2009. |
| 5. |
Katoh-Semba R, Kaneko R, Kitajima S, Tuzuki M, Ichisaka S1, Hata Y1, Yamada H, Miyazaki N, Takahashi Y2, Kato K (1Tottori Univ, 2Nara Med Univ)：Activation of p38 mitogen-activated protein kinase is required
for in vivo brain-derived neurotrophic factor production in the rat hippocampus.
Neuroscience 163: 352-361, 2009. |
| 2008年 |
| 1. |
Escher P1, Cottet S1, Aono S, Oohira A2, Schorderet D F1 (1 Univ of Lausanne, 2Aichi Med Univ): Differential neuroglycan C expression during retinal degeneration
in Rpe65－/－ mice. Mol Vis 14: 2126-2135, 2008. |
| 2. |
Sato Y1, Nakanishi K, Hayakawa M1, Kakizawa H1, Saito A1, Kuroda Y, Ida M, Tokita Y, Aono S, Matsui F, Kojima S1, and Oohira A2 (1Nagoya Univ, 2Aichi Med Univ): Reduction of brain injury in neonatal hypoxic-ischemic rats by intracerebroventricular injection of neural stem/progenitor cells together with chondroitinase ABC. Reprod Sci 15: 813-820, 2008. |
| 3. |
Sato Y1, Nakanishi K, Tokita Y, Kakizawa H1, Ida M, Maeda H2, Matsui F, Aono S, Saito A1, Kuroda Y, Hayakawa M1, Kojima S1 and Oohira A (1Nagoya Univ, 2Seikagaku Corp): A highly sulfated chondroitin sulfate preparation, CS-E,
prevents excitatory amino acid-induced neuronal cell death. J Neurochem 104: 1565-1576, 2008. |
| 4. |
Ichikawa M1, Yoshida J1, Saito K1, Sagawa H1, Tokita Y, Watanabe M (1Nagoya Univ): Differential effect of ROCK inhibitors, Fasudil and Y-27632,
on promotion of optic nerve regeneration in adult cats. Brain Res 1201:23-33, 2008. |
| 5. |
Tokime K1, Katoh-Semba R, Yamanaka K1, Akira Mizoguchi A1, Mizutani H1 (1Mie Univ) ： Enhanced production and secretion of glial cell line-derived neurotrophic factor and nerve growth factor from the skin in atopic dermatitis mouse model. Arch Dermatol Res 300: 343–352, 2008. |
| 6. |
Katoh-Semba R, Tsuzuki M, Miyazaki N, Matsuda M, Nakagawa C, Ichisaka S1, Sudo K, Kitajima S, Hamatake M, Hata Y1, Nagata K (1Tottori Univ)：A phase advance of the light-dark cycle stimulates production
of BDNF, but not of other neurotrophins, in the adult rat cerebral cortex:
association with the activation of CREB. J Neurochem 106: 2131–2142, 2008. |
| 7. |
Saitoh Y, Matsui F, Chiba Y, Kawamura N, Keino H, Satoh M, Kumagai N, Ishii
S, Yoshikawa K, Shimada A, Maeda N1, Oohira A, Hosokawa M (1Tokyo Metropolitan Institute for Neuroscience): Reduced expression of MAb6B4-epitopes
on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from
the cerebral cortices of SAMP10 mice, a model for age-dependent neurodegeneration.
J Neurosci Res 86: 1316-1323, 2008. |
| 2007年 |
| 1. |
Sadakata S1, Washida M1, Iwayama Y1, Shoji S1, Sato Y1, Ohkura T2, Katoh-Semba R, Makajima M1, Sekine Y1, Tanaka M1, Nakamura K3, Iwata Y3, Tuchiya KJ3, Mori N3, Detera-Waldeigh SD4, Ichikawa H2, Itohara S1, Yoshikawa T1, Furuichi T1 (1RIKEN, 2Umegaoka Hosp, 3Hamamatsu Univ, 4NIMH Betheda): Autistic-like phenotypes in CADPS2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest 117: 931-943, 2007. |
| 2. |
Katoh-Semba R, Wakako R1, Komori T1, Shigemi, H2, Miyazaki N, Ito H1, Kumagai T1, Tsuzuki, M, Shigemi K1, Yoshida Y1, Nakayama A (1Ctrl Hops, 2Tokai Kinen Hosp): Age-related changes in BDNF protein levels in human
serum: differences between autism cases and normal controls. Int J Dev Neurosci 25: 367-372, 2007. |
| 3. |
Katoh-Semba R, Tsuzuki, M, Miyazaki N, Yoshida A1, Nakajima H1, Nakagawa C, Kitajima S, Matsuda M (1Meiji Seika Kaisha Ltd): Distribution and immunohistochemical localization
of GDNF protein in selected neural and non-neural tissues of rats during
development and its changes in unilateral 6-hydroxydopamine lesions. Neurosci Res 59: 277-287, 2007. |
| 4. |
Kakizawa H1, Matsui F, Tokita Y, Hirano K, Ida M, Nakanishi K, Watanabe M, Sato Y1, Okumura A1, Kojima S1, and Oohira A (1Nagoya Univ): Neuroprotective effect of nipradilol, an NO donor, on hypoxic-ischemic brain injury of neonatal rats. Early Hum Dev 83: 535-540, 2007. |
| 5. |
Shuo T1, Aono S, Nakanishi K, Tokita Y, Kuroda Y, Ida M, Matsui F, Maruyama H1, Kaji T1, and Oohira A (1Hokuriku Univ): Ectodomain shedding of neuroglycan C, a brain-specific
chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3-sensitive proteolysis.
J Neurochem 102: 1561-1568, 2007. |
| 6. |
Yata T1, Nakamura M1, Sagawa H1, Tokita Y, Terasaki H1, Watanabe M (1Nagoya Univ): Survival and axonal regeneration of OFF-center retinal ganglion
cells of adult cats are promoted with an anti-glaucoma drug, nipradilol,
but not BDNF and CNTF. Neuroscience 148: 53-64, 2007. |
| 著書・総説 |
| 1. |
Nakanishi K, Sato Y1, Oohira A2 (1Nagoya Univ, 2Aichi Med Univ) Biological activities of highly sulfated chondroitin sulfate polysaccharides on neural cells. Global Research Network, Kerala, India, Research Advances in Neurochemistry 1, pp1-10, 2010. |
| 2. |
Nakanishi K, Oohira A1 (1Aichi Med Univ): Stem cell transplantation combined with niche modification:
A novel strategy for treatment of neurodegeneration. Electronic J Biol 4: 88-92, 2008. |
| 3. |
渡部眞三: ほ乳動物の視神経再生. 神経精神薬理28: 143-148, 2008. |
| 4. |
Matsui F: Chondroitin sulfate proteoglycans and neurotrophic factors. コンドロイチン硫酸プロテオグリカンと神経栄養因子.
Trends Glycosci Glycotechnl 20: 271-272, 2008. |
| 5. |
Matsui F, Oohira A: Structure and function of neurocan, a nervous-tissue chondroitin sulfate proteoglycan. Neural Proteoglycans, Maeda N ed, Research Signpost, Kerala, pp 21-36, 2007. |
| 6. |
Aono S, Oohira A: Neuroglycan C, a part-time proteoglycan, in the central
nervous system.Neural Proteoglycans, Maeda N ed, Research Signpost, Kerala, pp 37-50, 2007. |
| 7. |
中西圭子，大平敦彦：中枢神経系に特異的に発現するコンドロイチン硫酸プロテオグリカン．ニューログリカンCの機能，生化学 79,pp 370-374,
2007. |
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